Small molecule · Oncology
AR-117
Allosteric inhibitorPlaceholder
An allosteric approach to a target where active-site inhibitors have struggled with selectivity.
Development stage
- Discovery
- Lead optimisation
- Preclinical
- Clinical
Scientific rationale
- Cryptic pocket identified through molecular-dynamics simulation of the apo structure.
- Structure-aware generative models proposed chemotypes that no public library contained.