Therapeutic Modalities
The rightmodality
Some targets need a small molecule, others an antibody or a nucleic acid. We choose the modality that fits the biology — and design it with the same discipline.
- Small moleculesOral, tissue-penetrant, able to reach intracellular targets.
- AntibodiesExquisite specificity for extracellular and cell-surface targets.
- siRNA & mRNASilence a harmful gene or restore a missing protein.
- Gene therapyDurable correction for single-gene disorders.
Comparison
Matching modality to biology
| Modality | Best suited to | What our models optimise | Programmes |
|---|---|---|---|
| Small molecule | Intracellular enzymes, allosteric sites, CNS targets | Potency, selectivity, ADMET, synthesisability | 3 |
| Antibody | Cell-surface receptors, soluble ligands | Affinity, epitope, developability | 2 |
| siRNA | Liver-expressed disease genes | Knock-down potency, off-target seed matches | 1 |
| mRNA | Protein deficiency, transient expression | Codon usage, UTRs, stability | 1 |
| Gene therapy | Monogenic disorders | Capsid tropism, promoter, payload | 1 |
A target in search of a modality?
We assess tractability across all five modalities for every target we nominate.