Antibody · Immunology
AR-204
Immune-modulating antibodyPlaceholder
A humanised monoclonal antibody intended to dampen a pathological immune signalling axis implicated in chronic inflammatory disease.
Development stage
- Discovery
- Lead optimisation
- Preclinical
- Clinical
Scientific rationale
- Receptor prioritised from single-cell data of inflamed tissue versus healthy controls.
- Developability models screened out aggregation- and immunogenicity-prone variants early.
- Lead antibody binds with high affinity and blocks ligand signalling in primary-cell assays.